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KMID : 0357920130470030252
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Korean Journal of Pathology
2013 Volume.47 No. 3 p.252 ~ p.257
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Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma
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Ha Seung-Yeon
Ahn Jung-Suk
Roh Mee-Sook
Han Joung-Ho
Lee Jae-Jun
Lee Bo-In
Yim Jun
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Abstract
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Background: The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma. Methods: We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases were selected based on the histomorphology of ALK-rearranged lung adenocarcinoma. Results: Cytology showed mucinous (81.3%) and hemorrhagic (50%) backgrounds. The cells were arranged in tubulopapillary or tubulocribriform patterns (93.8%), and clusters (56.3%) admixed with signet ring cell features (87.5%). The tumor cells were monotonous and uniform with vesicular nuclei and a small nucleolus. Conclusions: The characteristic findings were sheets showing a tubulopapillary or tubulocribriform appearance, with vesicular nuclei and a bland chromatin pattern (p<0.001). Scattered signet ring cells were helpful in suggesting ALK-positive adenocarcinoma (p<0.001).
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KEYWORD
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Adenocarcinoma, Lung, Anaplastic lymphoma kinase, Carcinoma, non-small-cell lung, Cytology
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